Detection and characterization of atherosclerotic plaques by Raman probe spectroscopy and optical coherence tomography (Conference Presentation)

Christian Matthäus; Sebastian Dochow; Kokila D. Egodage; Iwan Schie; Bernd F. Romeike; Bernhard R. Brehm; Jürgen Popp

doi:10.1117/12.2252789

19 April 2017 Detection and characterization of atherosclerotic plaques by Raman probe spectroscopy and optical coherence tomography (Conference Presentation)

Christian Matthäus, Sebastian Dochow, Kokila D. Egodage, Iwan Schie, Bernd F. Romeike, Bernhard R. Brehm, Jürgen Popp

Author Affiliations +

Proceedings Volume 10042, Diagnostic and Therapeutic Applications of Light in Cardiology; 100420A (2017) https://doi.org/10.1117/12.2252789
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Visualization and characterization of inner arterial plaque depositions is of vital diagnostic interest. Established intravascular imaging techniques provide valuable morphological information, but cannot deliver information about the chemical composition of individual plaques. Probe based Raman spectroscopy offers the possibility for a biochemical characterization of atherosclerotic plaque formations during an intravascular intervention. From post mortem studies it is well known that the severity of a plaque and its stability are strongly correlated with its biochemical composition. Especially the identification of vulnerable plaques remains one of the most important and challenging aspects in cardiology. Thus, specific information about the composition of a plaque would greatly improve the risk assessment and management. Furthermore, knowledge about the composition can offer new therapeutic and medication strategies. Plaque calcifications as well as major lipid components such as cholesterol, cholesterol esters and triglycerides can be spectroscopically easily differentiated. Intravascular optical coherence tomography (OCT) is currently a prominent catheter based imaging technique for the localization and visualization of atherosclerotic plaque depositions. The high resolution of OCT with 10 to 15 µm allows for very detailed characterization of morphological features such as different plaque formations, thin fibrous caps and accurate measurements of lesion lengths. In combination with OCT imaging the obtained spectral information can provide substantial information supporting on on-site diagnosis of various plaque types and therefor an improved risk assessment. The potential and feasibility of combining OCT with Raman spectroscopy is demonstrated on excised plaque samples, as well as under in vivo conditions. Acknowledgements: Financial support from the Carl Zeiss Foundation is greatly acknowledged.

Conference Presentation

Citation Download Citation

Christian Matthäus, Sebastian Dochow, Kokila D. Egodage, Iwan Schie, Bernd F. Romeike, Bernhard R. Brehm, and Jürgen Popp "Detection and characterization of atherosclerotic plaques by Raman probe spectroscopy and optical coherence tomography (Conference Presentation)", Proc. SPIE 10042, Diagnostic and Therapeutic Applications of Light in Cardiology, 100420A (19 April 2017); https://doi.org/10.1117/12.2252789

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical coherence tomography

Raman spectroscopy

Spectroscopy

Optical spectroscopy

Visualization

Cardiology

Diagnostics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years