Clinical translation of photobiomodulation therapy using evidences from precision molecular pathway analyses (Conference Presentation)

Praveen Arany D.D.S.

doi:10.1117/12.2256307

19 April 2017 Clinical translation of photobiomodulation therapy using evidences from precision molecular pathway analyses (Conference Presentation)

Praveen Arany D.D.S.

Author Affiliations +

Proceedings Volume 10048, Mechanisms of Photobiomodulation Therapy XII; 100480B (2017) https://doi.org/10.1117/12.2256307
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Can ‘light’ be a Drug? To satisfy this definition as a pharmaceutical agent, light must be absorbed and change bodily function. Much evidence from our understanding of our visual cycle and Vitamin D metabolism have all noted this phenomenon. Advances in optophotonic technologies along with a better understanding of light-tissue interactions, especially in in vivo optical imaging and optogenetics, are spearheading the popularity of biophotonics in biology and medicine. The use of lasers and light devices at high doses in dermatology, ophthalmology, oncology and dentistry are now considered mainstream for certain clinical applications such as surgery, skin rejuvenation, ocular and soft tissue recontouring, anti-tumor and anti-microbial photodynamic therapy. In contrast, therapeutic use of low dose biophotonics devices is called Low Level Light / Laser Therapy (LLLT), now termed Photobiomodulation (PBM) Therapy. This therapy is defined as a non-thermal use of non-ionizing forms of electromagnetic radiation to alleviate pain, inflammation, modulating the immune responses and promoting wound healing and tissue regeneration. Surprisingly, despite vast volumes of scientific literature from both clinical and laboratory studies noting the phenomenological evidences for this innovative therapy, limited mechanistic insights have prevented the development of rigorous, reproducible clinical protocols. This presentation will outline our current efforts at ongoing efforts in our group to assess molecular pathways and precisely define clinical treatment variables to enable clinical translation with PBM therapies.

Conference Presentation

Citation Download Citation

Praveen Arany D.D.S. "Clinical translation of photobiomodulation therapy using evidences from precision molecular pathway analyses (Conference Presentation)", Proc. SPIE 10048, Mechanisms of Photobiomodulation Therapy XII, 100480B (19 April 2017); https://doi.org/10.1117/12.2256307

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KEYWORDS

Laser therapeutics

Biomedical optics

Biology

In vivo imaging

Laser vision correction

Medicine

Mode conditioning cables

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