Diffuse optical systems and methods to image physiological changes of the brain in response to focal TBI (Conference Presentation)

David Abookasis; Boris Volkov; Itamar Kofman

doi:10.1117/12.2251328

19 April 2017 Diffuse optical systems and methods to image physiological changes of the brain in response to focal TBI (Conference Presentation)

David Abookasis, Boris Volkov, Itamar Kofman

Author Affiliations +

Proceedings Volume 10050, Clinical and Translational Neurophotonics; 100500S (2017) https://doi.org/10.1117/12.2251328
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

During the last four decades, various optical techniques have been proposed and intensively used for biomedical diagnosis and therapy both in animal model and in human. These techniques have several advantages over the traditional existing methods: simplicity in structure, low-cost, easy to handle, portable, can be used repeatedly over time near the patient bedside for continues monitoring, and offer high spatiotemporal resolution. In this work, we demonstrate the use of two optical imaging modalities namely, spatially modulated illumination and dual-wavelength laser speckle to image the changes in brain tissue chromophores, morphology, and metabolic before, during, and after the onset of focal traumatic brain injury in intact mouse head (n=15). Injury was applied in anesthetized mice by weight-drop apparatus using ~50gram metal rod striking the mouse’s head. Following data analysis, we show a series of hemodynamic and structural changes over time including higher deoxyhemoglobin, reduction in oxygen saturation and blood flow, cell swelling, etc., in comparison with baseline measurements. In addition, to validate the monitoring of cerebral blood flow by the imaging system, measurements with laser Doppler flowmetry were also performed (n=5), which confirmed reduction in blood flow following injury. Overall, our result demonstrates the capability of diffuse optical modalities to monitor and map brain tissue optical and physiological properties following brain trauma.

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David Abookasis, Boris Volkov, and Itamar Kofman "Diffuse optical systems and methods to image physiological changes of the brain in response to focal TBI (Conference Presentation)", Proc. SPIE 10050, Clinical and Translational Neurophotonics, 100500S (19 April 2017); https://doi.org/10.1117/12.2251328

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KEYWORDS

Brain

Neuroimaging

Tissue optics

Traumatic brain injury

Biomedical optics

Blood circulation

Head

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