MR correlation spectroscopic imaging of multidimensional exponential decays: probing microstructure with diffusion and relaxation

Daeun Kim; Jessica L. Wisnowski; Justin P. Haldar

doi:10.1117/12.2272833

24 August 2017 MR correlation spectroscopic imaging of multidimensional exponential decays: probing microstructure with diffusion and relaxation

Daeun Kim, Jessica L. Wisnowski, Justin P. Haldar

Author Affiliations +

Proceedings Volume 10394, Wavelets and Sparsity XVII; 103940D (2017) https://doi.org/10.1117/12.2272833
Event: SPIE Optical Engineering + Applications, 2017, San Diego, California, United States

Abstract

Diffusion-relaxation correlation spectroscopic imaging (DR-CSI) is a novel multidimensional magnetic resonance (MR) imaging approach that we recently introduced for probing microstructure. DR-CSI uses high-dimensional MR data that is acquired with spatial encoding and non-separable diffusion-relaxation contrast encoding, and uses constrained image reconstruction to estimate a spectroscopic image with a multidimensional spectrum for each voxel. The spectral peaks correspond to distinct compartmental microenvironments that coexist within each voxel. This paper reviews DR-CSI and describes and demonstrates its generalization to other contrast mechanisms (i.e., we demonstrate multidimensional relaxation (T₁-T₂) correlation spectroscopic imaging).

Conference Presentation

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Daeun Kim, Jessica L. Wisnowski, and Justin P. Haldar "MR correlation spectroscopic imaging of multidimensional exponential decays: probing microstructure with diffusion and relaxation", Proc. SPIE 10394, Wavelets and Sparsity XVII, 103940D (24 August 2017); https://doi.org/10.1117/12.2272833

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