All-in-one theranostic nanoagent for head and neck cancer treatment

Tamar Dreifuss; Erez Shmuel Davidi; Menachem Motiei; Eran Barnoy; Dimitri Bragilovski; Leon Lubimov; Marc Jose Jonathan Kindler; Aron Popovtzer; Rachela Popovtzer

doi:10.1117/12.2289459

20 February 2018 All-in-one theranostic nanoagent for head and neck cancer treatment

Tamar Dreifuss, Erez Shmuel Davidi, Menachem Motiei, Eran Barnoy, Dimitri Bragilovski, Leon Lubimov, Marc Jose Jonathan Kindler, Aron Popovtzer, Rachela Popovtzer

Author Affiliations +

Proceedings Volume 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV; 1050614 (2018) https://doi.org/10.1117/12.2289459
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Despite the significant improvement in the treatment paradigm of head and neck cancer, owing to advanced radiation techniques in combination with chemotherapy, resistance of tumors remains a critical problem, leading to poor outcomes and negative prognosis. In addition, chemotherapeutic agents result in severe systemic toxicity due to nonselective damaging of normal cells. Recently, nanoparticle-based approaches have gained broad attention for improving both radiation therapy and chemotherapy. In this study, we present a dual effect nanoplatform, consists of gold nanoparticles coated with glucose and cisplatin (CG-GNPs), which simultaneously acts as a radiosensitizer and as a carrier which specifically deliver cisplatin to head and neck tumor. Our CG-GNPs showed significant penetration into tumor cells and similar cellular toxicity as cisplatin alone. Moreover, in combination with radiation treatment, CG-GNPs led to greater tumor reduction than that of free cisplatin with radiation. Furthermore, our CG-GNPs also demonstrated highly efficient imaging capabilities, as they act as ideal tumor-targeted CT contrast agent. Therefore, this single nano-formulation is a promising theranostic agent that has the potential to increase the antitumor effect and allow imaging guided therapy.

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Tamar Dreifuss, Erez Shmuel Davidi, Menachem Motiei, Eran Barnoy, Dimitri Bragilovski, Leon Lubimov, Marc Jose Jonathan Kindler, Aron Popovtzer, and Rachela Popovtzer "All-in-one theranostic nanoagent for head and neck cancer treatment", Proc. SPIE 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV, 1050614 (20 February 2018); https://doi.org/10.1117/12.2289459

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