Anisotropy factor reconstruction as a new endogenous contrast for cancer diagnosis with optical tomography

Ahmad Addoum; Sylvain Contassot-Vivier; Fatmir Asllanaj

doi:10.1117/12.2507418

1 March 2019 Anisotropy factor reconstruction as a new endogenous contrast for cancer diagnosis with optical tomography

Ahmad Addoum, Sylvain Contassot-Vivier, Fatmir Asllanaj

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108741X (2019) https://doi.org/10.1117/12.2507418
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In optical tomography, the reconstructions have only been limited to the absorption μ_a and scattering μ_s coefficients of biological tissues due to theoretical and computational limitations. In this study, The authors propose an efficient method to reconstruct, in 3D geometries, the anisotropy factor g of the Henyey-Greenstein phase function as a new optical contrast for cancer diagnosis. The light propagation in biological tissues is accurately modeled by the Radiative Transfer Equation (RTE) in the frequency domain. The adjoint method is used to efficiently compute the gradient of the objective function. A parallel implementation is carried out to reduce the computational times. The results show the robustness of the algorithm to reconstruct the g-factor for different contrast levels and for different initial guesses. The crosstalk problem between μ_s and g has been achieved with a reasonable quality which makes the new algorithm a candidate of choice to image this factor as new intrinsic contrast for optical imaging.

Citation Download Citation

Ahmad Addoum, Sylvain Contassot-Vivier, and Fatmir Asllanaj "Anisotropy factor reconstruction as a new endogenous contrast for cancer diagnosis with optical tomography", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741X (1 March 2019); https://doi.org/10.1117/12.2507418

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