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4 January 2019 Laser biosensor based on micromechanical oscillator
Timofey A. Efimov, Yuri N. Kulchin, Roman V. Romashko
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Proceedings Volume 11024, Asia-Pacific Conference on Fundamental Problems of Opto- and Microelectronics 2017; 110240G (2019) https://doi.org/10.1117/12.2519607
Event: Asia-Pacific Conference on Fundamental Problems of Opto- and Microelectronics 2017, 2017, Taipei, Taiwan
Abstract
We present laser microweight biosensor based on the adaptive holographic interferometer. The sensing element of the sensor is gold coated silicon microcantilever with dimensions of 210×40×5 μm3. Biomolecules of the interest being attached to the cantilever increase its mass which in its turn leads to decreasing the cantilever resonance frequency. The frequency shift of the detected signal is directly proportional to the total mass of adsorbed molecules. Cantilever oscillations are detected by the adaptive holographic interferometer based on two-wave mixing in a photorefractive CdTe crystal. For measuring the concentration of biological molecules dissolved in water the cantilever was installed in a cuvette which contains the solution. In the experiment, adsorbed molecules of BSA (Bovine Serum Albumin) with total mass of 3.1 ng were detected and weighted.
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Timofey A. Efimov, Yuri N. Kulchin, and Roman V. Romashko "Laser biosensor based on micromechanical oscillator", Proc. SPIE 11024, Asia-Pacific Conference on Fundamental Problems of Opto- and Microelectronics 2017, 110240G (4 January 2019); https://doi.org/10.1117/12.2519607
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KEYWORDS
Biosensors
Molecules
Interferometers
Sensors
Holograms
Holographic interferometry
Oscillators
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