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The papers in this volume were part of the technical conference cited on the cover and title page. Papers were selected and subject to review by the editors and conference program committee. Some conference presentations may not be available for publication. Additional papers and presentation recordings may be available online in the SPIE Digital Library at SPIEDigitalLibrary.org. The papers reflect the work and thoughts of the authors and are published herein as submitted. The publisher is not responsible for the validity of the information or for any outcomes resulting from reliance thereon. Please use the following format to cite material from these proceedings: Author(s), “Title of Paper,” in Diffuse Optical Spectroscopy and Imaging VII, edited by Hamid Dehghani, Heidrun Wabnitz, Proc. of SPIE-OSA Vol. 11074 (SPIE, Bellingham, WA, 2019) Seven-digit Article CID Number. ISSN: 1605-7422 ISSN: 2410-9045 (electronic) ISBN: 9781510628410 ISBN: 9781510628427 (electronic) Copublished by SPIE P.O. Box 10, Bellingham, Washington 98227-0010 USA Telephone +1 360 676 3290 (Pacific Time) · Fax +1 360 647 1445 SPIE.org and The Optical Society 2010 Massachusetts Ave., N.W., Washington, D.C., 20036 USA Telephone 1 202/223-8130 (Eastern Time) · Fax 1 202/223-1096 Copyright © 2019, Society of Photo-Optical Instrumentation Engineers and The Optical Society Copying of material in this book for internal or personal use, or for the internal or personal use of specific clients, beyond the fair use provisions granted by the U.S. Copyright Law is authorized by SPIE subject to payment of copying fees. The Transactional Reporting Service base fee for this volume is $21.00 per article (or portion thereof), which should be paid directly to the Copyright Clearance Center (CCC), 222 Rosewood Drive, Danvers, MA 01923. Payment may also be made electronically through CCC Online at copyright.com. Other copying for republication, resale, advertising or promotion, or any form of systematic or multiple reproduction of any material in this book is prohibited except with permission in writing from the publisher. The CCC fee code is 1605-7422/19/$21.00. Printed in the United States of America by Curran Associates, Inc., under license from SPIE. Publication of record for individual papers is online in the SPIE Digital Library. Paper Numbering: Proceedings of SPIE follow an e-First publication model. A unique citation identifier (CID) number is assigned to each article at the time of publication. Utilization of CIDs allows articles to be fully citable as soon as they are published online, and connects the same identifier to all online and print versions of the publication. SPIE uses a seven-digit CID article numbering system structured as follows:
AuthorsNumbers in the index correspond to the last two digits of the seven-digit citation identifier (CID) article numbering system used in Proceedings of SPIE. The first five digits reflect the volume number. Base 36 numbering is employed for the last two digits and indicates the order of articles within the volume. Numbers start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B…0Z, followed by 10-1Z, 20-2Z, etc. Abdalmalak, Androu, 2J Acharya, Deepshikha, 0Z Aizu, Yoshihisa, 1W, 2O Alves, Mariana, 06 Anazodo, Udunna, 14 Andersson-Engels, Stefan, 0R, 1C Aranda, Gloria, 10, 1L, 2T Arao, K., 1Z Arridge, Simon, 08, 26, 2I Azzarello, F., 24 Baez, Guido, 2N Bainbridge, Alan, 14 Baker, Wesley B., 0F Bale, Gemma, 06, 0P, 14 Balu, Ramani, 0F Baraldi, Eugenio, 0E Bassi, Andrea, 2I Beaudet, Jean, 16 Beaulieu, Emile, 25 Behera, Anurag, 02, 1A, 1B, 2Q Bejm, Karolina, 1J Belli, Antonio, 1A, 1B Beltran-Gonzalez, A., 1X Belyaev, A. V., 1V Bentley, Alexander, 12 Berdún, Sergio, 0X Berger, Michel, 1M, 27 Betcke, Marta, 2I Bettega, Georges, 27 Blaney, G., 0Y Bliznuks, Dmitrijs, 1O Bolochko, Katrina, 1O Bondarenko, Andrey, 1O Borycki, Dawid, 0B Bouthillier, Alain, 25 Bravo-Medina, B., 1X Bressel, Lena, 1P Brigadoi, Sabrina, 03, 05, 0E Burke, Ray, 0R Bürmen, Miran, 1Y, 29 Buttafava, Mauro, 04, 10, 2Q Cantow, Kathleen, 15 Chizhov, Yuriy, 1O Clemente, P., 1Z Climent, V., 1Z Cobelli, Claudio, 0E Coll, Jean-Luc, 27 Colombo, L., 11, 2V Colombo, R., 1K Condat, Laurent, 09, 1B Conde, Olga M., 1G Contini, Davide, 02, 04, 0T, 10, 11, 1E, 1K, 1L, 24, 2Q, 2R, 2T, 2V Cooper, Robert J., 03, 05, 0E Cortese, Lorenzo, 0X, 10, 1L, 2T Cross, J. Helen, 06 Cubeddu, Rinaldo, 0A, 1K, 2M Culver, Joseph P., 0H, 0M, 11 Cutini, Simone, 0E Da Silva, Anabela, 0Q, 2S Dabrowski, Wojciech, 1J Dalla Mora, Alberto, 02, 04, 08, 10, 11, 1A, 1B, 1L, 2Q, 2T, 2V D’Andrea, Cosimo, 2I, 2U Das, Kaustav, 1W de Fraguier, S., 10, 1L De Roever, Isabel, 06 Dean, Emma, 06 Dehghani, Hamid, 0L, 0P, 10, 12, 1A, 1B, 1I, 2D Dell’Acqua, Roberto, 0E Di Sciacca, Giuseppe, 08, 26 Di Sieno, Laura, 02, 08, 11, 2Q, 2T Diop, Mamadou, 14 Dolenec, Rok, 1S Dolgyshkin, Dmitry A., 1R Dot, Audrey, 27 Duan, Jinming, 2C Dudnikov, S. Y., 1V Dunne, Luke, 03 Durduran, Turgut, 0L, 0X, 10, 11, 1A, 1B, 1L, 2S, 2T, 2V Eggebrecht, Adam T., 0H, 0M Eixarch, Elisenda, 0X Everdell, Nick, 03 Faber, Dirk J., 2K Fantini, S., 0Y Farina, Andrea, 08, 26, 2I, 2M, 2T, 2U Feng, Yangqin, 1I Ferocino, Edoardo, 08, 26 Fishell, Andrew K., 0H Flanders, Tracy M., 0F Flemming, Bert, 15 Flibotte, John J., 0F Forcione, Mario, 1A, 1B Foschum, Florian, 2A Francis, K. J., 2M Frolov, O. O., 1Q, 23 Fujii, Hiroyuki, 07 Funamizu, Hideki, 1W, 2O Galderisi, Alfonso, 0E Ganglani, Aman, 05 García, E., 10 García, Héctor, 2N Garcia-Torales, G., 1X Gerega, Anna, 22 Germinario, Bruno, 0T Giacalone, Giacomo, 0T Giannoni, Luca, 13 Gjvaag, Terje, 20 Gladytz, Thomas, 0A, 15 Gomis, R., 10, 1L Goryacheva, Irina Yu., 19 Gratacós, Eduard, 0X Grosenick, Dirk, 0A, 15, 2N, 2W Gunther, Jacqueline, 0R Gurevich, B. S., 1V Hanzu, F., 10, 1L Hashisaka, Tomoki, 1W, 2O He, Lian, 0F Hebden, Peter, 06 Henry, Maxime, 27 Hervé, Lionel, 09, 1A, 1B Herzog, Bernd, 1P Heuer, Gregory G., 0F Heye, Kristina, 0F Hill, Reuben, 03 Hirsch, Ole, 2W Hoshi, Yoko, 07 Hu, Xin-Hua, 2G Isler, Helene, 1E, 22 Issar, Deepa, 0Z Jallon, Pierre, 09, 16 Jauregui-Sánchez, Y., 1Z Jayet, Baptiste, 0R Jezeršek, Matija, 2E Jin, Jiahong, 2G Josè Torra, F., 10 Kacprzak, Michal, 0B, 1J Kainerstorfer, Jana M., 0Z Kawaguchi, Hiroshi, 07 Kewin, Matthew, 14, 2J Khalid, Mahro, 2J Kienle, Alwin, 0N, 2A Koberling, Felix, 02 Kobori, Yuta, 1W Kochubey, Vyacheslav I., 19 Koenig, Anne, 16 Kofke, W. Andrew, 0F Konugolu Venkata Sekar, Sanathana, 0A, 10, 11, 1C, 1L, 2M, 2U, 2V Kovácsová, Zuzana, 0P, 1A, 1B Krämer, Benedikt, 02 Krischak, K., 10 Kruit, Hindrik, 2M Lacerenza, M., 04, 2U Lakota, Katja, 1S Lancis, J., 1Z Lange, Frédéric, 0V, 13, 22 Lanka, Pranav, 0A, 1A, 1B, 1C, 2M, 2Q Lartizien, Rodolphe, 27 Laurence, Audrey, 25 Lazarev, Vladimir A., 1R Leblond, Frederic, 25 Lenz, A. J. M., 1Z Li, Haiyang, 1C Liang, Po-Jian, 2H Licht, Daniel J., 0F Liebert, Adam, 0B, 1A, 1B, 1J, 22, 28 Lighter, Daniel, 1I Lihachev, Alexey, 1O Lihacova, Ilze, 1O Likar, Boštjan, 1Y, 29 Liu, Linshan, 14 Liu, Yan, 0C Lo Presti, Giuseppe, 0X, 10, 1L, 2T López-Higuera, José M., 1G Lu, Jun Q., 2G Lu, Wenqi, 2C Macdonald, Callum M., 0Q, 2S Macdonald, Rainer, 0A Machida, Manabu, 07, 21 Maeda, Takaaki, 2O Mahanna Gabrielli, Elizabeth, 0F Malek, Mokrane, 16 Maniewski, Roman, 1J, 28 Manohar, Srirang, 2M Marchesi, L., 04 Maria Frijia, Elisabetta, 03 Markel, Vadim A., 0Q, 2S Markova, Maria D., 1R Mars, Jérôme, 09, 1B Martella, Pierluigi, 1C Martelli, Fabrizio, 08 Marzorati, M., 24 Masuda, Yuji, 2O Mateo, Tony, 2T Melih Can, Osman, 1T Meseyarakov, V. D., 1Q Messenio, D., 1K Milanič, Matija, 1S, 2E Milej, Daniel, 2J Mimura, Tetsuya, 07 Mirtaheri, Peyman, 20 Mora, Mireia, 10, 1L, 2T Morawiec, Magdalena, 1J, 28 Morrison, Laura, 14 Mutisya, Stephen M., 2G Naglič, Peter, 1Y, 29 Nakamura, G., 0S Navolokin, Nikita A., 19 Nguyen, Dang K., 25 Ni, Ruiqing, 0C Niendorf, Thoralf, 15 Nothelfer, Steffen, 2A Ohya, Takehiro, 1W Okada, Eiji, 07, 0S, 2L Okawa, Shinpei, 07 Orive-Miguel, David, 09, 1A, 1B Ostojic, Daniel, 1E, 22 Oulhaj, Hind, 0Q Pacheco, Andrea, 1C Pagliazzi, M., 11, 2V Panizza, Pietro, 2T Pardo, Arturo, 1G Pavlovčič, Urban, 2E Pedrique, Belen, 1M Pernuš, Franjo, 1Y, 29 Perriollat, Mathieu, 27 Perše, Martina, 1S Petitdidier, Nils, 16 Pham, T., 0Y Pieropan, Edoardo, 0E Pifferi, Antonio, 02, 04, 08, 0A, 10, 11, 1A, 1B, 1C, 1E, 1L, 26, 2M, 2T, 2U, 2V Pinti, Paola, 06 Pirovano, Ileana, 1K, 24, 2R Planat-Chrétien, Anne, 1M, 27 Pogue, Brian W., 1G Pohlmann, Andreas, 15 Polatoglu, Mavi Nunn, 0C Porcelli, S., 24 Post, Anouk L., 2K Pouet, Marina, 16 Powell, Samuel, 03 Pugachov, E. I., 1Q Pulawski, Przemyslaw, 1J Rajaram, Ajay, 14, 2J Re, Rebecca, 0T, 1K, 24, 2R Reich, Oliver, 1P Reighley, S., 1X Ren, Wuwei, 0C Renna, Marco, 04, 10, 2Q Ripoll, Jorge, 0C Rogelj, Luka, 2E Rohilla, Sumeet, 02 Rosinski, Bogdan, 10, 1L, 2T Roveri, Luisa, 0T Rowe, Jonathan E., 12 Rudin, Markus, 0C Ruesch, Alexander, 0Z Samaei, Saeed, 0B, 1A, 1B Sassaroli, A., 0Y Sawosz, Piotr, 0B, 1A, 1B, 1J, 22, 28 Schädel-Ebner, Sandra, 2W Schira, Katrin, 2W Schmitt, Samantha, 0Z Schroeder, Mariel L., 0H Seeliger, Erdmann, 15 Shahid, Marwan, 2J Shapovalov, V. V., 1V Sherafati, Arefeh, 0H Sherkat, Habib, 20 Shirai, T., 2L Simončič, Urban, 2E Smith, Greg, 03 Smith, Matthew A., 0Z Sparacino, Giovanni, 0E Spinelli, Lorenzo, 0T, 1E, 1K, 24, 2R, 2V Squarcia, Mattia, 10, 1L, 2T St. Lawrence, Keith, 14, 2J Stergar, Jošt, 1S Strojnik, M., 1X Styles, Iain B., 2C Sudakou, Aleh, 1A, 1B, 22 Svoboda, Alexa M., 0H Tachtsidis, Ilias, 06, 0P, 0V, 13, 14, 1A, 1B, 22 Tagliabue, Susanna, 1A, 1B Tajahuerce, E., 1Z Tanikawa, Yukari, 07 Taroni, Paola, 08, 10, 1L, 26, 2T Thiebot, Alain, 16 Thornton, Rachel, 06 Tian, Peng, 2G Tihov, Ivan, 23 Timchenko, Elena V., 1Q, 1R, 23 Timchenko, Pavrel E., 1Q, 1R, 23 Tomšič, Matija, 1S Torricelli, Alessandro, 02, 04, 0T, 11, 1B, 1E, 1K, 24, 2R, 2V Tosi, Alberto, 04, 10, 2Q Trevisanuto, Daniele, 0E Tricoli, Ugo, 0Q, 2S Trudel, Dominique, 25 Tseng, Sheng-Hao, 2H Tuchin, Valery V., 19 Ülgen, Yekta, 1T Uteshev, Dilshat, 1O Valentini, Gianluca, 2I, 2U van Leeuwen, Ton G., 2K Veesa, Joshua Deepak, 0P, 1A, 1B, 2C, 2D Venturini, Elena, 2T Vezyroglou, Aikaterini, 06 Vidal-Rosas, E. E., 11 Vidyasheva, Irina V., 19 Volova, Larisa T., 1Q, 1R, 23 Wabnitz, Heidrun, 0A, 1A, 1B, 1E, 2N Wang, Yan, 1I Wanji, Samuel, 1M Weigel, Udo M., 0L, 10, 1E, 1L Wojak, Julien, 0Q Wojtkiewicz, Stanislaw, 0L, 10 Wolf, Martin, 0C, 1E, 22 Worley, Alan, 06 Yagofarova, E. F., 23 Yang, Jason, 0Z Yang, Lin, 0A, 1A, 1B Yanina, Irina Yu, 19 Yodh, Arjun G., 0F Yuasa, Tomonori, 1W, 2O Zagorsky, I. G., 1V Zanoletti, Marta, 0T, 10, 2Q Zappa, F., 04 Zelinskyi, Yevhen, 1Y Zhang, Lei, 1I Zhao, Hubin, 03, 05 Zolda, P., 10 Zoller, Christian, 0N Conference CommitteeGeneral Chair
Programme Chairs Conference Chairs
Conference Programme Committee
Session Chairs
IntroductionThe 2019 European Conferences on Biomedical Optics were held in Munich from June 23rd – 27th. The Diffuse Optical Spectroscopy and Imaging conference has continued to grow in the last decade and attracted over 105 submissions in 2019. This resulted in over 55 oral and 50 poster presentations from a range of international research groups, showing the significance of this conference for scientific exchange in this field in Europe and worldwide. We have seen an enormous amount of development in Diffuse Optical Spectroscopy and Imaging, ranging from system development and testing to data analysis and advanced clinical applications. A major development seen in systems and technologies presented at this conference has been towards miniaturisation and wearable systems, both for continuous-wave spectroscopic and time-domain instrumentation. This enables new applications in complex real-life environments, such as comfortable measurements on young children or measurements during exercise in adults. As diffuse optics technology has developed and our understanding of signal origins has improved, the use of multi-modality systems has also increased. Exciting work was presented to demonstrate that the use of broadband spectroscopic data together with diffuse correlation spectroscopy allows unique measurements of metabolism from the human brain to be obtained. The combination of optical and other technologies, such as ultrasound, was also prominent at the conference tackling important clinical problems such as detecting and characterising thyroid cancer. Human brain health has remained a significant topic of research within the conference and many excellent contributions seeking a better understanding of brain health and identifying disease and trauma were presented. A look at these proceedings will show that the use of diffuse optics, being either through measurement of haemodynamic changes, oxygenation, or blood flow within humans is an active area of research. Many groups demonstrated validation of these measurements with current gold-standard techniques. As system development has advanced, the community is becoming more aware regarding performance assessment and validation of instrumentation and data analysis. For the first time, we had two dedicated sessions to Phantoms and Standardisation as well as Open-Source Software which highlighted the importance of sharing knowledge in both areas. This also included impressive work highlighting the importance of not only making well-characterized phantoms for system validation, but also of further developing them as a relevant factor in international standardisation. We are very excited to share these proceedings with the community and thank all contributors. We are confident that as the community grows, the importance and applications of diffuse optical imaging and spectroscopy will also continue to grow. We are looking forward to our next meeting in 2021. Hamid Dehghani Heidrun Wabnitz |