Short and mid-term reproducibility analysis of cerebral tissue saturation measured by time domain-NIRS

F. Lange; I. Tachtsidis

doi:10.1117/12.2526780

11 July 2019 Short and mid-term reproducibility analysis of cerebral tissue saturation measured by time domain-NIRS

F. Lange, I. Tachtsidis

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110740V (2019) https://doi.org/10.1117/12.2526780
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

The short- (i.e. over minutes) and mid-term (i.e. over days/weeks) reproducibility of cerebral tissue saturation measured by time domain-NIRS (TD-NIRS) is investigated in this work. We present a pilot study that assess the reproducibility of the measurement of the tissue saturation (StO₂) of the prefrontal cortex on a sample of 7 healthy adult volunteers. TDNIRS measurements were acquired at 16 wavelengths, from 780 to 870 nm, in steps of 6 nm, and were fitted with the diffusion model for semi-infinite homogenous media. Then the absolute concentration of oxy- and deoxyhemoglobin ([HbO₂], [HHb]) were calculated using Beer-Lambert’s law, in order to calculate the volunteer’s brain tissue saturation (StO₂ = [HbO₂]/([HbO₂]+[HHb])). Three measurement sessions were performed on three different days (within a week interval) to evaluate the mid-term reproducibility of the StO₂. For each session, three measurements were taken (within 10 minutes, with repositioning of the probes) to evaluate the short-term reproducibility of the StO₂. The reproducibility was expressed as the within-volunteer standard deviation (SD_w), calculated using a one-way repeated-measure ANOVA. The SD_w in session 1, 2 and 3 were 0.89%, 1.10% and 0.82% respectively, showing a good short-term reproducibility, and the SD_w for all 3 sessions was 1.43%, showing a good mid-term reproducibility without significant variations in the StO₂ between the 3 sessions. Moreover, the mean ± SD global values of StO₂ over all the measurements (n=63) is 62.8+/- 4.2% which is close to the values reported in the literature for adults.

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F. Lange and I. Tachtsidis "Short and mid-term reproducibility analysis of cerebral tissue saturation measured by time domain-NIRS", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110740V (11 July 2019); https://doi.org/10.1117/12.2526780

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KEYWORDS

Near infrared spectroscopy

Tissues

Brain

Time metrology

Absorption

Tissue optics

Data processing

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