Evaluation of singlet oxygen production of a novel chlorin photosensitizer

Jian Zou; Jie Jiang; Zhen Han; Rui Ding; Zheng Huang

doi:10.1117/12.2526579

22 July 2019 Evaluation of singlet oxygen production of a novel chlorin photosensitizer

Jian Zou, Jie Jiang, Zhen Han, Rui Ding, Zheng Huang

Proceedings Volume 11079, Medical Laser Applications and Laser-Tissue Interactions IX; 110790L (2019) https://doi.org/10.1117/12.2526579
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Photodynamic therapy (PDT) utilizes the combined action of photosensitizer, light, and molecular oxygen to generate reactive singlet oxygen (¹O₂) to treat various diseases. Photosensitizer is a key component in PDT and its singlet oxygen quantum yield determines the effectiveness of its photodynamic reaction. This study evaluated the singlet oxygen production of a novel water soluble chlorin photosensitizer (YLG-I) using a ¹O₂-specificfluorescence probe - Singlet Oxygen Sensor Green reagent (SOSG). The spectra and singlet oxygen luminescence in different solvents were evaluated using mTHPC as a reference. It was estimated and verified that the singlet oxygen quantum yield of the new photosensitizer YLG-I was at the same level of the potent chlorin sensitizer mTHPC. Preliminary evaluation suggested that YLG-I was a promising photosensitizer for PDT.

Citation Download Citation

Jian Zou, Jie Jiang, Zhen Han, Rui Ding, and Zheng Huang "Evaluation of singlet oxygen production of a novel chlorin photosensitizer", Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110790L (22 July 2019); https://doi.org/10.1117/12.2526579

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