LED-based portable light source for photodynamic therapy

O. Chepurna; A. Grebinyk; Yu. Petrushko; S. Prylutska; S. Grebinyk; V. M. Yashchuk; O. Matyshevska; U. Ritter; T. Dandekar; M. Frohme; J. Qu; T. Y. Ohulchanskyy

doi:10.1117/12.2541774

20 November 2019 LED-based portable light source for photodynamic therapy

O. Chepurna, A. Grebinyk, Yu. Petrushko, S. Prylutska, S. Grebinyk, V. M. Yashchuk, O. Matyshevska, U. Ritter, T. Dandekar, M. Frohme, J. Qu, T. Y. Ohulchanskyy

Author Affiliations +

Proceedings Volume 11190, Optics in Health Care and Biomedical Optics IX; 111901A (2019) https://doi.org/10.1117/12.2541774
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

Photodynamic therapy (PDT) employs light activation of tissue-localized photosensitizer in an oxygen-dependent process which initiates oxidative stress, inflammation, and cell death. Laser systems, which are mostly used in PDT as light sources can be costly and oversized. light-emitting diodes (LEDs) equipment has a high potential to simplify technical part of phototriggered therapies and to reduce its costs. We develop the LED-based system that includes the control and irradiation units. The system provides the same power density at any irradiation point. Among the advantages of the device is a possibility to change the irradiation area and tune the irradiation dose. PDT experiments with cancer cells in vitro treated with two different photosensitizers demonstrated a possibility to use the developed LED-based system as a low-cost light source in PDT.

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O. Chepurna, A. Grebinyk, Yu. Petrushko, S. Prylutska, S. Grebinyk, V. M. Yashchuk, O. Matyshevska, U. Ritter, T. Dandekar, M. Frohme, J. Qu, and T. Y. Ohulchanskyy "LED-based portable light source for photodynamic therapy", Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111901A (20 November 2019); https://doi.org/10.1117/12.2541774

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