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Ulcerative Colitis (UC) is an idiopathic autoimmune inflammatory disorder of the colon mucosa characterized by leukocyte infiltration into the submucosa and ulcer formation in the epithelium, followed by epithelial cell proliferation and restitution of the mucosal barrier. Optical methods sensitive to tissue oxygen demand and epithelial cell metabolism are ideally suited for clinical guidance of disease progression and remission in UC. Here we present endoscopic reporters of submucosal oxygen demand (i.e. inflammatory-related changes) and epithelial cell metabolism (i.e. mucosal re-epithelialization) within the ulcer bed and surrounding microenvironment in a murine model of UC as putative biomarkers of mucosal healing.
Ariel I. Mundo,Elizabeth Bullard,Kyle P. Quinn, andTimothy J. Muldoon
"Optical spectroscopic and imaging biomarkers of ulcerative colitis disease progression and remission (Conference Presentation)", Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 1121605 (9 March 2020); https://doi.org/10.1117/12.2543369
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Ariel I. Mundo, Elizabeth Bullard, Kyle P. Quinn, Timothy J. Muldoon, "Optical spectroscopic and imaging biomarkers of ulcerative colitis disease progression and remission (Conference Presentation)," Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 1121605 (9 March 2020); https://doi.org/10.1117/12.2543369