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9 March 2020 Optical spectroscopic and imaging biomarkers of ulcerative colitis disease progression and remission (Conference Presentation)
Ariel I. Mundo, Elizabeth Bullard, Kyle P. Quinn, Timothy J. Muldoon
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Proceedings Volume 11216, Multiscale Imaging and Spectroscopy; 1121605 (2020) https://doi.org/10.1117/12.2543369
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Ulcerative Colitis (UC) is an idiopathic autoimmune inflammatory disorder of the colon mucosa characterized by leukocyte infiltration into the submucosa and ulcer formation in the epithelium, followed by epithelial cell proliferation and restitution of the mucosal barrier. Optical methods sensitive to tissue oxygen demand and epithelial cell metabolism are ideally suited for clinical guidance of disease progression and remission in UC. Here we present endoscopic reporters of submucosal oxygen demand (i.e. inflammatory-related changes) and epithelial cell metabolism (i.e. mucosal re-epithelialization) within the ulcer bed and surrounding microenvironment in a murine model of UC as putative biomarkers of mucosal healing.
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Ariel I. Mundo, Elizabeth Bullard, Kyle P. Quinn, and Timothy J. Muldoon "Optical spectroscopic and imaging biomarkers of ulcerative colitis disease progression and remission (Conference Presentation)", Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 1121605 (9 March 2020); https://doi.org/10.1117/12.2543369
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KEYWORDS
Ocean optics
Spectroscopy
Imaging spectroscopy
Endoscopy
Optical imaging
Optical spectroscopy
Optical spectroscopy imaging
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