Fingerprinting individual bio-nanoparticles by interferometric photothermal microscopy (Conference Presentation)

Celalettin Yurdakul; Haonan Zong; Yeran Bai; M. Selim Ünlü; Ji-Xin Cheng

doi:10.1117/12.2546489

10 March 2020 Fingerprinting individual bio-nanoparticles by interferometric photothermal microscopy (Conference Presentation)

Celalettin Yurdakul, Haonan Zong, Yeran Bai, M. Selim Ünlü, Ji-Xin Cheng

Author Affiliations +

Proceedings Volume 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine; 112521P (2020) https://doi.org/10.1117/12.2546489
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Chemical characterization of biological specimens in the mid-infrared (IR) window plays a central role in the analysis of their functionalities. Although recent advances in mid-IR microscopy have demonstrated detection of the sample’s chemical contrast at a sub-micron resolution using a visible probe beam, they have limited sensitivity at high-throughput. To overcome this limit, we employ wide-field interferometric microscopy to detect the minute change in the optical path induced by mid-IR absorption. Our technique enables high-speed fingerprinting of more than thousands of sub-200 nm nanoparticles at once. This method paves the way for high-throughput, ultrasensitive, and label-free chemical imaging of individual bio-nanoparticles at sub-micron resolution.

Conference Presentation

Citation Download Citation

Celalettin Yurdakul, Haonan Zong, Yeran Bai, M. Selim Ünlü, and Ji-Xin Cheng "Fingerprinting individual bio-nanoparticles by interferometric photothermal microscopy (Conference Presentation)", Proc. SPIE 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine, 112521P (10 March 2020); https://doi.org/10.1117/12.2546489

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