Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging

Zhen Yuan; Duyang Gao

doi:10.1117/12.2542233

21 February 2020 Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging

Zhen Yuan, Duyang Gao

Proceedings Volume 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII; 112540K (2020) https://doi.org/10.1117/12.2542233
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Controllable preparation of water-soluble multifunctional nanoprobes is of great significance for cancer early diagnosis. In this study, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared region are developed in the presence of halide ions. Further, DTPA-Gd3+ is conjugated on it by using the unique characteristics of the protein-protected nanotriangles. Specifically, the asobtained nanostructures are investigated as contrast agents for enhanced in vivo photoacoustic/magnetic resonance dual-modal tumor imaging. More importantly, in vitro and in vivo toxicity analysis are also performed, which show that the dual -modal nanoprobes are biocompatible for most of the cases. It is demonstrated that the novel asprepared protein-modified nanotriangles are able to work as a nanoplatform to construct dual-modal nanoprobes, which paves a new anenue for improving the photoacoustic/magnetic resonance imaging contrast in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.

Conference Presentation

Citation Download Citation

Zhen Yuan and Duyang Gao "Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging", Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 112540K (21 February 2020); https://doi.org/10.1117/12.2542233

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