Opening the BBB could disable neurovascular coupling: the quantitative mathematical model prediction

Robert I. Loshkarev; Dmitry E. Postnov

doi:10.1117/12.2565794

9 April 2020 Opening the BBB could disable neurovascular coupling: the quantitative mathematical model prediction

Proceedings Volume 11459, Saratov Fall Meeting 2019: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 114590Q (2020) https://doi.org/10.1117/12.2565794
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

The concept of neurovascular unit (NVU) is used to denote cells and their communication mechanisms involved in the formation of autoregulation of blood supply. It has been shown that the "opening" of blood-brain barrier (BBB) can be caused by different types of effects, such as a strong and prolonged sound, or by laser irradiation. It has been noted that the BBB opening is accompanied by perivascular edema, as capillary permeability to water also increases many times. Thus, one can expect that such changes can significantly affect the operational mode of neurovascular unit. We present the model study aimed to estimate the impact of perivascular edema on the functioning of neurovascular coupling using a multidimensional quantitative mathematical model. Our results predict the blocking of neurovascular communication operation when BBB is opened. Namely, we show that a relatively small (2-3 times) change in perivascular volume has a subtle effect, a 10-fold increase in PVS changes markedly, but does not violate the functionality of neurovascular coupling, and a significant degree of edema (increase in PVS more than 100 times) almost completely turns off the neurovascular coupling.

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Robert I. Loshkarev and Dmitry E. Postnov "Opening the BBB could disable neurovascular coupling: the quantitative mathematical model prediction", Proc. SPIE 11459, Saratov Fall Meeting 2019: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 114590Q (9 April 2020); https://doi.org/10.1117/12.2565794

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KEYWORDS

Neurons

Potassium

Mathematical modeling

Blood brain barrier

Neurovascular coupling

Calcium

Ion channels

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