Synthesis of antibiotic-silver nanoparticles complexes, their properties, and application for investigation of antibiotic-resistance mechanisms

A. D. Karachkovska; V. J. Syrvatka; O. M. Gromyko; V. O. Fedorenko

doi:10.1117/12.2567974

21 August 2020 Synthesis of antibiotic-silver nanoparticles complexes, their properties, and application for investigation of antibiotic-resistance mechanisms

A. D. Karachkovska, V. J. Syrvatka, O. M. Gromyko, V. O. Fedorenko

Author Affiliations +

Proceedings Volume 11467, Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XVII; 1146721 (2020) https://doi.org/10.1117/12.2567974
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Conference Poster

Abstract

Synthesis of silver nanoparticles (AgNPs) with varied modifications of their surfaces helps to diversify and adjust nanoparticles for applying in new science areas. Complexes of antibiotics with AgNPs can be effective against resistant bacteria and become a sensitive tool for antibiotic-resistance mechanisms’ investigations. The main aim of the study was synthesized of AgNPs complexes with various antibiotics and study of their properties for application in investigation and overcoming of antibiotic-resistance mechanisms. Stable complexes of silver nanoparticles with ampicillin, cefotaxime, ceftriaxone, cefuroxime, chloramphenicol, ristomycin, teicoplanin and vanсomycin were obtained. The obtained nanoparticles were spherical with a size of 10-12 nm. The concentration of argentum in the final solutions was 55 μM, the concentration of antibiotic was 10 μM, except for vanсomycin and teicoplanin was 1 μM. The most stable in ethanol solution are the complexes of silver nanoparticles with teicoplanin, chloramphenicol and vanсomycin. The optimal storage temperature for teicoplanin, vanсomycin, ristomycin and chloramphenicol complex, is 4° C. The obtained complexes of antibiotics with AgNPs are more stable in alkaline media than in solutions with acidic pH. Bactericidal activity of all synthesized complexes of antibiotics with silver nanoparticles was higher in comparison with the corresponding solutions of antibiotics without nanoparticles.

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A. D. Karachkovska, V. J. Syrvatka, O. M. Gromyko, and V. O. Fedorenko "Synthesis of antibiotic-silver nanoparticles complexes, their properties, and application for investigation of antibiotic-resistance mechanisms", Proc. SPIE 11467, Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XVII, 1146721 (21 August 2020); https://doi.org/10.1117/12.2567974

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