In-vivo corneal biomechanics measurement by 3D trackable Brillouin microscopy

Hongyuan Zhang; Giuliano Scarcelli; James Bradley Randleman

doi:10.1117/12.2577061

5 March 2021 In-vivo corneal biomechanics measurement by 3D trackable Brillouin microscopy

Hongyuan Zhang, Giuliano Scarcelli, James Bradley Randleman

Proceedings Volume 11645, Optical Elastography and Tissue Biomechanics VIII; 116450S (2021) https://doi.org/10.1117/12.2577061
Event: SPIE BiOS, 2021, Online Only

Abstract

Brillouin microscopy has been applied successfully to in-vivo corneal imaging to understand stiffness variation along different phases of keratoconus. However, the in-vivo spatial resolution is restricted due to a conflict between a slow Brillouin acquisition rate of hundreds of milliseconds and human movement during acquisition. In this research, frequency domain optical coherence tomography and image tracking are proved to be effective methods to locate points measured by Brillouin microscopy in axial and radial directions, respectively. Results show that OCT has an accuracy of better than 2 μm while image tracking has an accuracy better than 3 μm.

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Hongyuan Zhang, Giuliano Scarcelli, and James Bradley Randleman "In-vivo corneal biomechanics measurement by 3D trackable Brillouin microscopy", Proc. SPIE 11645, Optical Elastography and Tissue Biomechanics VIII, 116450S (5 March 2021); https://doi.org/10.1117/12.2577061

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KEYWORDS

Optical coherence tomography

Cornea

In vivo imaging

Microscopy

Optical tracking

Fourier transforms

Optical filters

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