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5 March 2021 Electric-field molecular fingerprinting of blood: new prospects for probing human health
Mihaela Zigman, Ferenc Krausz
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Proceedings Volume 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021; 116550Z (2021) https://doi.org/10.1117/12.2587329
Event: SPIE BiOS, 2021, Online Only
Abstract
Recent advances in ultrafast laser science have opened new prospects in probing living systems. Suddenly-excited molecular vibrations emit picosecond-duration coherent infrared light characteristic of the sample’s composition. Given the capacity of this electric-field molecular fingerprint (EMF) to cross-molecularly probe organic samples, we evaluate the feasibility of EMF for biomedical diagnostics. We report high stability of EMF over time and show that several cancer entities leave their signatures in the EMF of serum. Leveraging on the advances of stability, reproducibility and sensitivity of EMF, we provide foundation for applications of infrared molecular profiles in the preventive care model of health monitoring.
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Mihaela Zigman and Ferenc Krausz "Electric-field molecular fingerprinting of blood: new prospects for probing human health", Proc. SPIE 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021, 116550Z (5 March 2021); https://doi.org/10.1117/12.2587329
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KEYWORDS
Blood
Infrared radiation
Biomedical optics
Diagnostics
Infrared detectors
Spectroscopy
Thermal modeling
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