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1 August 2021 Multiplex connectome changes across the Alzheimer’s spectrum
Anna Canal Garcia, Emiliano Gómez Ruiz, Mite Mijalkov, Giovanni Volpe, Joana B. Pereira
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Proceedings Volume 11804, Emerging Topics in Artificial Intelligence (ETAI) 2021; 118040P (2021) https://doi.org/10.1117/12.2593316
Event: SPIE Nanoscience + Engineering, 2021, San Diego, California, United States
Abstract
The organization of the Alzheimer's disease (AD) connectome has been studied using single neuroimaging modalities. However, different neuroimaging modalities are not independent and often interact with each other in the course of AD. Here, we integrate the networks obtained from T1-weighted and 18F-Florbetapir PET to build a multiplex connectome using BRAPH 2.0 and assess how it changes across different AD stages. We assessed the overlapping strength, multilayer communities, overlapping connections, and the multiplex participation and clustering coefficients. There was a reorganization of the communities across the four groups and we found significant changes reflecting a loss of multiplex hubs and overlapping connections in medial frontal and occipital areas in the patients’ groups. These findings indicate that multiplex network changes can be useful to understand the relationship between amyloid pathology and gray matter atrophy occurring over the course of AD.
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Anna Canal Garcia, Emiliano Gómez Ruiz, Mite Mijalkov, Giovanni Volpe, and Joana B. Pereira "Multiplex connectome changes across the Alzheimer’s spectrum", Proc. SPIE 11804, Emerging Topics in Artificial Intelligence (ETAI) 2021, 118040P (1 August 2021); https://doi.org/10.1117/12.2593316
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KEYWORDS
Alzheimer's disease
Brain
Neuroimaging
Pathology
Positron emission tomography
Magnetic resonance imaging
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