Preliminary study of surface-enhanced Raman spectroscopy (SERS) of serum samples of liver cancer patients

Qiwen Wang; Mengmeng Zheng; Yuhong Fang; Kecan Lin; Shusen Xie; Zheng Huang

doi:10.1117/12.2602627

9 October 2021 Preliminary study of surface-enhanced Raman spectroscopy (SERS) of serum samples of liver cancer patients

Qiwen Wang, Mengmeng Zheng, Yuhong Fang, Kecan Lin, Shusen Xie, Zheng Huang

Author Affiliations +

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 119000U (2021) https://doi.org/10.1117/12.2602627
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Abstract

Background: Liver cancer is a leading cause of cancer mortality in China. Early diagnosis and treatment play a significant role in reducing liver cancer mortality. Aims: In this preliminary study, the feasibility of using surface enhanced Raman spectroscopy (SERS) of serum to identify primary liver cancer was explored. Materials and methods: Serum samples were obtained from liver cancer patients (n = 25) and healthy controls (n = 30). Nano-silver (Ag) colloids (45 ± 6 nm) were used as the SERS substrate and mixed with serum samples (10 μL). Raman spectra were obtained from a confocal Raman micro-spectrometer (Renishaw) and spectral characteristics analyzed. Results: Analyses of spectral characteristics showed noticeable differences in peak heights between the mean spectra of the control and patients, mainly reflected in following peak positions: increased at 496, 593, 637, 726, 813, 888, and 1137 cm^-1, and decreased at 1580 cm^-1, respectively. Which might be attributable to glycogen, phosphatidylinositol, aminoacid methionine, C-S (protein), C-C stretching, methylene rocking, palmitic acid and C-C stretching, respectively. Conclusion: These preliminary analyses suggest that SERS might be useful for the identification of serum markers of liver cancer.

Conference Presentation

Citation Download Citation

Qiwen Wang, Mengmeng Zheng, Yuhong Fang, Kecan Lin, Shusen Xie, and Zheng Huang "Preliminary study of surface-enhanced Raman spectroscopy (SERS) of serum samples of liver cancer patients", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 119000U (9 October 2021); https://doi.org/10.1117/12.2602627

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