Interferometric diffusing speckle contrast imaging (iDSCI) system for monitoring regional cerebral blood flow

Guang Han; Qianbei Guo; Siqi Chen; Hao Feng; Xinzheng Yu; Huiquan Wang

doi:10.1117/12.2601290

9 October 2021 Interferometric diffusing speckle contrast imaging (iDSCI) system for monitoring regional cerebral blood flow

Guang Han, Qianbei Guo, Siqi Chen, Hao Feng, Xinzheng Yu, Huiquan Wang

Author Affiliations +

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 1190025 (2021) https://doi.org/10.1117/12.2601290
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Conference Poster

Abstract

For specific cerebrovascular diseases such as epilepsy and Alzheimer's disease, it is urgent to detect the chronic changes of regional cerebral blood flow (rCBF) for a long time. interferometric diffusing wave spectroscopy (iDWS) based on optical heterodyne detection is expected to improve the detection sensitivity and reduce the interference of scalp blood flow. However, iDWS technology is difficult to achieve two-dimensional blood flow imaging. Therefore, this research proposes a interferometric diffusing speckle contrast imaging (iDSCI) system for monitoring rCBF, which combines an improved diffusion speckle contrast analysis method with iDWS technology. The dynamic phantom experiment demonstrated a good linear relationship between the reconstructed relative blood flow index and the actual flow velocity, and multi-parameter analysis validated the effectiveness of the iDSCI system in monitoring rCBF velocity, improving detection accuracy from 0.82 to 0.97. Therefore, the iDSCI system has the potential to provides a new theoretical basis for the early diagnosis and treatment of cerebrovascular diseases in the future.

Conference Presentation

Citation Download Citation

Guang Han, Qianbei Guo, Siqi Chen, Hao Feng, Xinzheng Yu, and Huiquan Wang "Interferometric diffusing speckle contrast imaging (iDSCI) system for monitoring regional cerebral blood flow", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 1190025 (9 October 2021); https://doi.org/10.1117/12.2601290

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