Micro-lens arrays (MLA)-assisted fractional photothermal therapy for effective cancer treatment

Hyejin Kim; Hanjae Pyo; Hyeonsoo Kim; Hyun Wook Kang

doi:10.1117/12.2614305

7 December 2021 Micro-lens arrays (MLA)-assisted fractional photothermal therapy for effective cancer treatment

Hyejin Kim, Hanjae Pyo, Hyeonsoo Kim, Hyun Wook Kang

Proceedings Volume 11919, Translational Biophotonics: Diagnostics and Therapeutics; 1191903 (2021) https://doi.org/10.1117/12.2614305
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

Conventional photothermal therapy (PTT) of cancer typically utilizes an end-firing flat fiber (Flat) to deliver optical energy, leading to incomplete treatment of target cells due to a Gaussian-shaped non-uniform beam profile. The current study demonstrates a therapeutic capacity of micro-lens arrays (MLA)-assisted laser irradiation to enhance photothermal effects. Computational and experimental validations are performed on gelatin phantoms and aqueous dye solutions to compare photothermal responses of Flat and MLA. In vivo tumor-bearing mouse models are developed to evaluate a therapeutic capacity of MLA-assisted PTT. Evaluations with both phantom and aqueous solution present that the MLA-assisted laser treatment accompanies a wider and more uniform beam distribution, compared to the Flat-based treatment. The in vivo results confirmed that the MLA-assisted laser treatment induced spatially-consistent tumor necrosis on account of uniform temperature distribution. The proposed MLA application can be a feasible method to help achieve the complete tumor removal without recurrence.

Citation Download Citation

Hyejin Kim, Hanjae Pyo, Hyeonsoo Kim, and Hyun Wook Kang "Micro-lens arrays (MLA)-assisted fractional photothermal therapy for effective cancer treatment", Proc. SPIE 11919, Translational Biophotonics: Diagnostics and Therapeutics, 1191903 (7 December 2021); https://doi.org/10.1117/12.2614305

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available