Challenges of transcranial photoacoustic imaging for human at 2.25 MHz: an ex vivo study

Loïc Saint-Martin; Mohsin Zafar; Rayyan Manwar; Kamran Avanaki

doi:10.1117/12.2613034

3 March 2022 Challenges of transcranial photoacoustic imaging for human at 2.25 MHz: an ex vivo study

Loïc Saint-Martin, Mohsin Zafar, Rayyan Manwar, Kamran Avanaki

Proceedings Volume 11960, Photons Plus Ultrasound: Imaging and Sensing 2022; 119600Y (2022) https://doi.org/10.1117/12.2613034
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

In transcranial brain imaging, the presence of the skull represents a challenge in the generation of clear signals. For the human skull, and animals with a thick skull, optical and ultrasound propagations are significantly degraded due to the bone properties. First, the optical and acoustic transmission and attenuation after crossing the skull bone are separately identified. Optical measurements are performed in the range of 690 to 940 nm in order to determine the transmission at different regions of the skull; the total hemoglobin absorption coefficient is considered for the imaging target. Then, the impact of the skull thickness on the ultrasound propagation through the bone is evaluated using 2.25 MHz transducers. In the second part, photoacoustic imaging on the frontal, parietal and occipital bones are evaluated. In addition to the skull thickness variation, the angle of illumination and the depth of the imaged target are studied. Based on the results we determine regions of the human head where transcranial photoacoustic imaging at 2.25 MHz is feasible, taking advantage of the good resolution due to the high frequency.

Citation Download Citation

Loïc Saint-Martin, Mohsin Zafar, Rayyan Manwar, and Kamran Avanaki "Challenges of transcranial photoacoustic imaging for human at 2.25 MHz: an ex vivo study", Proc. SPIE 11960, Photons Plus Ultrasound: Imaging and Sensing 2022, 119600Y (3 March 2022); https://doi.org/10.1117/12.2613034

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