Introduction to retrosynthetic analysis: basic concepts, simplification methods, and application

Luyu Li; Jiawei Yu; Yang Zhao

doi:10.1117/12.2646165

5 August 2022 Introduction to retrosynthetic analysis: basic concepts, simplification methods, and application

Luyu Li, Jiawei Yu, Yang Zhao

Proceedings Volume 12326, 2nd International Conference on Materials Chemistry and Environmental Engineering (CONF-MCEE 2022); 123260F (2022) https://doi.org/10.1117/12.2646165
Event: 2nd International Conference on Materials Chemistry and Environmental Engineering (CONF-MCEE 2022), 2022, ONLINE, United States

Abstract

Retrosynthetic analysis is the cornerstone of organic synthesis, allowing scientists to simplify complex target molecules into small fragments by disconnecting bonds. This review details basic concepts and common simplifying methods that scientists used in the retrosynthetic analysis. By using straightforward language and rich examples, the beginners can gain an overall understanding of retrosynthetic analysis and start to use techniques that they learned in this review to design synthetic pathways on paper. The last part provides a possible synthetic pathway for dihydrolucilactaene, a new potent drug for malaria, using the simplifying methods mentioned above.

Citation Download Citation

Luyu Li, Jiawei Yu, and Yang Zhao "Introduction to retrosynthetic analysis: basic concepts, simplification methods, and application", Proc. SPIE 12326, 2nd International Conference on Materials Chemistry and Environmental Engineering (CONF-MCEE 2022), 123260F (5 August 2022); https://doi.org/10.1117/12.2646165

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