Beneath the skin: multi-frequency SFDI to detect thin layers of skin using light scattering

Luigi Belcastro; Hanna Jonasson; Tomas Strömberg; Ahmed Elserafy; Rolf B. Saager

doi:10.1117/12.2648545

14 March 2023 Beneath the skin: multi-frequency SFDI to detect thin layers of skin using light scattering

Luigi Belcastro, Hanna Jonasson, Tomas Strömberg, Ahmed Elserafy, Rolf B. Saager

Proceedings Volume 12352, Photonics in Dermatology and Plastic Surgery 2023; 1235209 (2023) https://doi.org/10.1117/12.2648545
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Wound healing assessment is usually performed visually by a trained physician. This type of evaluation is very subjective and returns limited information about the wound progression. In contrast, optical imaging techniques are non-invasive ways to quantitatively measure biological parameters. Spatial frequency domain imaging (SFDI) is an optical technique that exploits sinusoidal patterns of light with multiple spatial frequencies to measure the tissue frequency-specific response, from which the absorption and scattering coefficient of the material can be derived. While SFDI is based on models of light transport that assume the tissue is homogeneous, skin is composed by several layer with very different optical properties. An underutilized property of SFDI, however, is that the spatial frequency of the patterns determines the penetration depth of photons in the tissue. By using multiple ranges of spatial frequencies, we are developing a means to obtain morphological data from different volumes of tissue. This data is used to reconstruct the optical properties in depth, allowing us to differentiate between different thin layers of tissue. In this study we have developed a 2-layer optical phantom model with realistic optical properties and dimensions, that mimics the physiology of wound healing. We have used this physical model to validate the accuracy of this approach in obtaining layer specific optical properties.

Conference Presentation

Citation Download Citation

Luigi Belcastro, Hanna Jonasson, Tomas Strömberg, Ahmed Elserafy, and Rolf B. Saager "Beneath the skin: multi-frequency SFDI to detect thin layers of skin using light scattering", Proc. SPIE 12352, Photonics in Dermatology and Plastic Surgery 2023, 1235209 (14 March 2023); https://doi.org/10.1117/12.2648545

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available