Raman macroscopic imaging system for intraoperative brain cancer detection

Patrick Orsini; Joannie Desroches; François Daoust; Hugo Tavera; Frédérick Dallaire; Keven Savard; Jacques Bismuth; Philippe Mckoy; Israel Veilleux; Kevin Petrecca; Frédéric Leblond

doi:10.1117/12.2668370

14 March 2023 Raman macroscopic imaging system for intraoperative brain cancer detection

Patrick Orsini, Joannie Desroches, François Daoust, Hugo Tavera, Frédérick Dallaire, Keven Savard, Jacques Bismuth, Philippe Mckoy, Israel Veilleux, Kevin Petrecca, Frédéric Leblond

Author Affiliations +

Proceedings Volume 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; 123610H (2023) https://doi.org/10.1117/12.2668370
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

We present a macroscopic line scanning Raman imaging system which has been modified to be suitable for intraoperative use. A sterilizable probe muzzle was designed to flatten the biological tissue ensuring its position at the focal plane of the Raman probe optics, removing the need for probe sterilization. The system uses a flexible imaging probe with a 1cm² field of view to record fingerprint Raman images, mounted on an articulated arm that supports the probe weight and allows gentle contact with the tissue. Validation results obtained on porcine tissues show >95% classification accuracy between different tissue types.

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Patrick Orsini, Joannie Desroches, François Daoust, Hugo Tavera, Frédérick Dallaire, Keven Savard, Jacques Bismuth, Philippe Mckoy, Israel Veilleux, Kevin Petrecca, and Frédéric Leblond "Raman macroscopic imaging system for intraoperative brain cancer detection", Proc. SPIE 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, 123610H (14 March 2023); https://doi.org/10.1117/12.2668370

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