Microsphere-assisted microscopy: challenges and opportunities

Arash Darafsheh; Vahid Abbasian

doi:10.1117/12.2681499

15 August 2023 Microsphere-assisted microscopy: challenges and opportunities

Arash Darafsheh, Vahid Abbasian

Proceedings Volume 12618, Optical Measurement Systems for Industrial Inspection XIII; 126180L (2023) https://doi.org/10.1117/12.2681499
Event: SPIE Optical Metrology, 2023, Munich, Germany

Abstract

Optical microscopy is one the oldest and most widely used techniques for sample inspection in life and material sciences. Microsphere-assisted microscopy (MAM) has emerged as a simple yet efficient approach to boost the spatial resolution. MAM uses a microsphere, placed in the immediate vicinity of the object, to enhance the numerical aperture and improve the resolution. MAM can be used in conjunction with white-light, wide-field, bright-field, dark-field, confocal, fluorescent, second harmonic generation, two-photon, interferometric, and digital holographic microscopies. It can be employed in reflection and transmission modes. There are several open questions and challenges associated with MAM, including the resolution limit, the mechanism behind resolution improvement, and the limited imaging field-of-view. Here, we present the progress in MAM in the past decade along with the associated opportunities and challenges.

Conference Presentation

Citation Download Citation

Arash Darafsheh and Vahid Abbasian "Microsphere-assisted microscopy: challenges and opportunities", Proc. SPIE 12618, Optical Measurement Systems for Industrial Inspection XIII, 126180L (15 August 2023); https://doi.org/10.1117/12.2681499

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