High-fidelity quantitative differential phase contrast deconvolution using dark-field sparse prior

Shuhe Zhang; Tao Peng; Zeyu Ke; Meng Shao; Tos T. J. M. Berendschot; Jinhua Zhou

doi:10.1117/12.2683923

18 July 2023 High-fidelity quantitative differential phase contrast deconvolution using dark-field sparse prior

Shuhe Zhang, Tao Peng, Zeyu Ke, Meng Shao, Tos T. J. M. Berendschot, Jinhua Zhou

Proceedings Volume 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023); 127450X (2023) https://doi.org/10.1117/12.2683923
Event: Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 2023, Haikou, China

Abstract

Differential Phase Contrast (DPC) imaging plays an important role in the family of quantitative phase measurement. However, the reconstruction algorithm for quantitative DPC (qDPC) imaging is not yet optimized, as it does not incorporate the inborn properties of qDPC imaging. In this research, we propose a simple but effective image prior, the Dark-field Sparse Prior (DSP), to facilitate the phase reconstruction quality for all DPC-based phase reconstruction algorithms. The DSP is based on the key observation that most pixel values for an idea differential phase contrast image are zeros since the subtraction of two images under anti-symmetric illumination cancels all background components. With this DSP prior, we formed a new cost function in which L0-norm was used to represent the DSP. Further, we developed the algorithm based on the Half Quadratic Splitting to solve this NP-hard L0-norm problem. We tested our new model on both simulated and experimental data and compare it against State-Of-The-Art (SOTA) methods including L2-norm and total variation regularizations. Results show that our proposed model is superior in terms of phase reconstruction quality and implementation efficiency, which significantly increases the experimental robustness, while maintaining the data fidelity. In general, the DSP supports high-fidelity qDPC reconstruction without any modification of the optical system, which simplifies the system complexity and benefit all qDPC applications.

Citation Download Citation

Shuhe Zhang, Tao Peng, Zeyu Ke, Meng Shao, Tos T. J. M. Berendschot, and Jinhua Zhou "High-fidelity quantitative differential phase contrast deconvolution using dark-field sparse prior", Proc. SPIE 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 127450X (18 July 2023); https://doi.org/10.1117/12.2683923

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KEYWORDS

Digital signal processing

Image restoration

Reconstruction algorithms

Image deconvolution

Image denoising

Phase imaging

Phase retrieval

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