Quantitative OCT angiography for blood flow analysis in mouse embryonic cardiovascular system

Michaela A. McCown; Irina V. Larina

doi:10.1117/12.3005708

13 March 2024 Quantitative OCT angiography for blood flow analysis in mouse embryonic cardiovascular system

Michaela A. McCown, Irina V. Larina

Proceedings Volume 12819, Diagnostic and Therapeutic Applications of Light in Cardiology 2024; 128190O (2024) https://doi.org/10.1117/12.3005708
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Biomechanical force exerted by early blood flow regulates heart development and alterations can result in congenital heart defects. To investigate dynamics during early cardiac development in mouse models of human disease, optical coherence tomography (OCT) based functional analysis methods are actively being developed. Here, by integrating and expanding recent OCT cardiodynamic techniques, we demonstrate a quantitative OCT angiography method capable of dynamic, volumetric flow analysis in embryonic vasculature and within the beating heart. The presented method will allow biomechanical studies of the role that early blood flow plays in regulating mammalian heart development.

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Michaela A. McCown and Irina V. Larina "Quantitative OCT angiography for blood flow analysis in mouse embryonic cardiovascular system", Proc. SPIE 12819, Diagnostic and Therapeutic Applications of Light in Cardiology 2024, 128190O (13 March 2024); https://doi.org/10.1117/12.3005708

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KEYWORDS

Blood circulation

Heart

Optical coherence tomography

Angiography

Cardiovascular system

Biomechanics

Statistical analysis

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