Polarization-sensitive investigation of outer retinal OCT bands in the human eye

Shaiban Ahmed; Taeyoon Son; Xincheng Yao

doi:10.1117/12.3002871

12 March 2024 Polarization-sensitive investigation of outer retinal OCT bands in the human eye

Shaiban Ahmed, Taeyoon Son, Xincheng Yao

Proceedings Volume 12824, Ophthalmic Technologies XXXIV; 128240N (2024) https://doi.org/10.1117/12.3002871
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

This study addresses the debated topic of the anatomic origins of the second and third outer retinal bands in optical coherence tomography (OCT). Given the complexity of biological tissue composition and cellular arrangement, pinpointing the precise source of outer retinal OCT signals is challenging. We explored this issue using a polarization-controlled full-field OCT (FF-OCT) system, capitalizing on the fact that light polarization can be modified by the birefringence and scattering properties of biological tissues. Quantitative comparison of cross-polarized and parallel-polarized OCT images supports that the second outer retinal band encompasses contributions from both the ellipsoid zone (EZ) and the inner segment/outer segment (IS/OS) junction, while the third band appears to reflect contributions from both the interdigitation zone (IZ) and photoreceptor OS tips. The comparative analysis of cross-polarized and parallel-polarized OCT images not only aids in understanding the anatomic correlates of OCT signals but also holds promise for offering new biomarkers of ocular conditions.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Shaiban Ahmed, Taeyoon Son, and Xincheng Yao "Polarization-sensitive investigation of outer retinal OCT bands in the human eye", Proc. SPIE 12824, Ophthalmic Technologies XXXIV, 128240N (12 March 2024); https://doi.org/10.1117/12.3002871

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