Development of a patient-friendly optical imaging system for simultaneous monitoring arthritis in multiple finger joints of patients with systemic lupus erythematosus

Moegammad A. Bardien; Alessandro Marone; Xin Wang; Shane Murray; Wei Tang; Sean Inzerillo; Vedant Gaikwad; Leila Khalili; Stephen H. K. Kim; Anca D. Askanase; Andreas H. Hielscher

doi:10.1117/12.3003896

27 March 2024 Development of a patient-friendly optical imaging system for simultaneous monitoring arthritis in multiple finger joints of patients with systemic lupus erythematosus

Moegammad A. Bardien, Alessandro Marone, Xin Wang, Shane Murray, Wei Tang, Sean Inzerillo, Vedant Gaikwad, Leila Khalili, Stephen H. K. Kim, Anca D. Askanase, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics; 128500P (2024) https://doi.org/10.1117/12.3003896
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

We have developed an optical imaging system that allows monitoring arthritis in systemic lupus erythematosus (SLE) patients in multiple finger joints simultaneously. This system addresses the need for a low-cost accurate way to quickly assess SLE in a patient friendly manner. system comprises multiple flexible optical bands for each finger. Each band includes eight sets of three light-emitting-diodes (LEDs) (wavelength λ = 880 nm, 660 nm, and 530 nm) and a photodiode and can be wrapped around a proximal inter-phalangeal (PIP) joint allowing for the measurement of reflected and transmitted light from the LEDs by the photodetector. 24 LEDs and 8 detectors combine for a total of 192 measurements per finger per frame, which is acquired at a frame rate of 1 frame per second. We tested the performance of the system in a clinical pilot study comparing the results to an existing single-band system that makes measurements on one PIP joint at a time. During data acquisition, a partial venous inclusion is induced using a blood pressure cuff inflated to the subject’s diastolic blood pressure. Initial results show statistically significant differences between SLE patient and healthy volunteers, agreeing with our previous findings single-band technology.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Moegammad A. Bardien, Alessandro Marone, Xin Wang, Shane Murray, Wei Tang, Sean Inzerillo, Vedant Gaikwad, Leila Khalili, Stephen H. K. Kim, Anca D. Askanase, and Andreas H. Hielscher "Development of a patient-friendly optical imaging system for simultaneous monitoring arthritis in multiple finger joints of patients with systemic lupus erythematosus", Proc. SPIE 12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics, 128500P (27 March 2024); https://doi.org/10.1117/12.3003896

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available