Research progress of microglia involvement in the pathogenesis of Alzheimer's disease

Puzhi Yu

doi:10.1117/12.3013153

8 January 2024 Research progress of microglia involvement in the pathogenesis of Alzheimer's disease

Puzhi Yu

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129243K (2024) https://doi.org/10.1117/12.3013153
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of extracellular beta-amyloid protein and intracellular highly phosphorylated tau protein. The clinical characteristics include progressive deterioration of memory ability and cognitive function. Microglia are mononuclear macrophages resident in the central nervous system, playing an important role in maintaining brain development and homeostasis. In the pathological process of AD, microglia with normal physiological function can phagocytize and clear neurotoxic substances, also participate in the maturation and construction of central neural network. However, under the stimulation of inflammatory environment, aging, loss of functional proteins, and expression of risk factors, microglia cells become polarized and over-activated resulting in accumulation of neurotoxic substances, releases of pro-inflammatory factors, and adverse consequences of excessive neuronal cleavage, thus accelerating the development of AD. Therefore, to explain the double-edged role of microglia in AD pathogenesis, here we reviewed the basic biological functions of microglia, and discussed how the relevant factors contribute to the functional changes in microglia. Additionally, possible mechanisms are summarized to explain how these changes contributes to AD progression.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Puzhi Yu "Research progress of microglia involvement in the pathogenesis of Alzheimer's disease", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129243K (8 January 2024); https://doi.org/10.1117/12.3013153

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available