Transcriptional signatures of macroscopic cortical structure alternations in major depressive disorder

Jinpeng Niu; Jie Xia; Wei Liao

doi:10.1117/12.3057810

13 February 2025 Transcriptional signatures of macroscopic cortical structure alternations in major depressive disorder

Jinpeng Niu, Jie Xia, Wei Liao

Author Affiliations +

Proceedings Volume 13539, Sixteenth International Conference on Graphics and Image Processing (ICGIP 2024); 135392F (2025) https://doi.org/10.1117/12.3057810
Event: Sixteenth International Conference on Graphics and Image Processing (ICGIP 2024), 2024, Nanjing, China

Abstract

The onset and symptoms of Major Depressive Disorder (MDD) are associated with abnormalities in macroscopic brain structure. Revealing the relationship between macroscopic brain structure and microscopic transcriptional signatures could promote the understanding of the pathogenesis of MDD. Here, case-control differences in regional Morphometric Inverse Divergence (MIND) were calculated to measure MDD-related morphometric alternations. The relationship between MIND differences and brain-wide gene expression was further examine. The expression of related genes was spatially correlated with MIND differences. Furthermore, genes correlated with MIND changes showed significant enrichments in inflammation- and metabolism-related processes. Dysregulation of astrocyte, microglia and neuronal cells may be an important factor leading to MDD-related MIND alternations. Collectively, these findings link structural abnormalities and microscopic transcriptional signatures, promoting the understanding of the pathogenesis of MDD.

(2025) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Jinpeng Niu, Jie Xia, and Wei Liao "Transcriptional signatures of macroscopic cortical structure alternations in major depressive disorder", Proc. SPIE 13539, Sixteenth International Conference on Graphics and Image Processing (ICGIP 2024), 135392F (13 February 2025); https://doi.org/10.1117/12.3057810

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