Spray-jet assembly interface for the coupling of reversed-phase        narrow-bore LC and FTIR spectrometry

G. W. Somsen; Cees Gooijer; Udo A. T. Brinkman; Nel H. Velthorst; Tom Visser; A. P. J. M. de Jong

doi:10.1117/12.56475

1 March 1992 Spray-jet assembly interface for the coupling of reversed-phase narrow-bore LC and FTIR spectrometry

G. W. Somsen, Cees Gooijer, Udo A. T. Brinkman, Nel H. Velthorst, Tom Visser, A. P. J. M. de Jong

Proceedings Volume 1575, 8th Intl Conf on Fourier Transform Spectroscopy; (1992) https://doi.org/10.1117/12.56475
Event: Eighth International Conference on Fourier Transform Spectroscopy, 1991, Lubeck-Travemunde, Germany

Abstract

Reversed phase liquid chromatography (RPLC) has been coupled to Fourier transform infrared spectrometry (FTIR) via solvent elimination and effluent deposition using a spray jet assembly. The chromatographic separation is hardly affected. Identification limits are in the 10 - 20 ng range. The system can handle eluent containing up to 40% water. The usefulness of the interface in impurity profiling of steroids is demonstrated.

Citation Download Citation

G. W. Somsen, Cees Gooijer, Udo A. T. Brinkman, Nel H. Velthorst, Tom Visser, and A. P. J. M. de Jong "Spray-jet assembly interface for the coupling of reversed-phase narrow-bore LC and FTIR spectrometry", Proc. SPIE 1575, 8th Intl Conf on Fourier Transform Spectroscopy, (1 March 1992); https://doi.org/10.1117/12.56475

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