Photodynamic therapy with chlorin e6 dose-effect relation on an inoculated rat tumor model

Ivan N. Zhuravkin; Gennady Kostenich; G. P. Gurinovich; Edvard A. Zhavrid M.D.

doi:10.1117/12.137030

5 March 1993 Photodynamic therapy with chlorin e6 dose-effect relation on an inoculated rat tumor model

Ivan N. Zhuravkin, Gennady Kostenich, G. P. Gurinovich, Edvard A. Zhavrid M.D.

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137030
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

The antitumor effect of photodynamic treatment with chlorin e₆ was studied. A transplantable rat tumor (sarcoma M-1) was irradiated by krypton ion laser light after chlorin e₆ injection at different doses of photoradiation (22.5 - 180 J/cm²) and photosensitizer (1 - 10 mg/kg). The time interval between chlorin e₆ intravenous injection and photoradiation was varied from 15 min to 72 hours. Tumor growth inhibition coefficient (TGIC), tumor regression rate, and cure of animals were used as antitumor criteria of photodynamic treatment. It was found that the antitumor effect of photodynamic therapy was in direct relationship to the chlorin e₆ dose and light energy exposure value and in the inverse one to the time interval between photosensitizer injection and photoradiation.

Citation Download Citation

Ivan N. Zhuravkin, Gennady Kostenich, G. P. Gurinovich, and Edvard A. Zhavrid M.D. "Photodynamic therapy with chlorin e6 dose-effect relation on an inoculated rat tumor model", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137030

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