Photosensitizer dosage: mg/kg or mg/m2 of body surface?

James S. McCaughan M.D.; Cynthia Miller

doi:10.1117/12.146320

18 June 1993 Photosensitizer dosage: mg/kg or mg/m2 of body surface?

James S. McCaughan M.D., Cynthia Miller

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146320
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The effect of different doses of the photosensitizer dihematoporphyrin ether (DHE) on the percent decrease of obstruction by endobronchial tumors produced by photodynamic therapy (PDT) was compared on the basis of mg/kg of body weight and mg/m² of body surface. We found statistically significant differences in the effect of different mg/m² when there was no difference when compared on the basis of mg/kg of body weight. There was an increase and then a decrease in the effectiveness as the mg/m² increased. We do not know how to interpret this. However, mg/m² provides a better parameter for effectiveness and we are now using 60 mg/m² of DHE for treating endobronchial tumors on the same day as the injection.

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James S. McCaughan M.D. and Cynthia Miller "Photosensitizer dosage: mg/kg or mg/m2 of body surface?", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146320

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