Brain proton magnetic resonance spectroscopy for hepatic encephalopathy

Chin-Sing Ong; James R. McConnell; Wei-Kom Chu

doi:10.1117/12.151176

27 August 1993 Brain proton magnetic resonance spectroscopy for hepatic encephalopathy

Chin-Sing Ong, James R. McConnell, Wei-Kom Chu

Proceedings Volume 1887, Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods; (1993) https://doi.org/10.1117/12.151176
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Liver failure can induce gradations of encephalopathy from mild to stupor to deep coma. The objective of this study is to investigate and quantify the variation of biochemical compounds in the brain in patients with liver failure and encephalopathy, through the use of water- suppressed, localized in-vivo Proton Magnetic Resonance Spectroscopy (HMRS). The spectral parameters of the compounds quantitated are: N-Acetyl Aspartate (NAA) to Creatine (Cr) ratio, Choline (Cho) to Creatine ratio, Inositol (Ins) to Creatine ratio and Glutamine-Glutamate Amino Acid (AA) to Creatine ratio. The study group consisted of twelve patients with proven advanced chronic liver failure and symptoms of encephalopathy. Comparison has been done with results obtained from five normal subjects without any evidence of encephalopathy or liver diseases.

Citation Download Citation

Chin-Sing Ong, James R. McConnell, and Wei-Kom Chu "Brain proton magnetic resonance spectroscopy for hepatic encephalopathy", Proc. SPIE 1887, Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods, (27 August 1993); https://doi.org/10.1117/12.151176

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KEYWORDS

Liver

Brain

Magnetic resonance imaging

Data acquisition

Failure analysis

Chromium

Data processing

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