Time-resolved analysis of laser-induced photothermal stress in blood clots

German Da Costa

doi:10.1117/12.182731

17 August 1994 Time-resolved analysis of laser-induced photothermal stress in blood clots

German Da Costa

Proceedings Volume 2137, Time-Resolved Laser Spectroscopy in Biochemistry IV; (1994) https://doi.org/10.1117/12.182731
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Blood clots are illuminated with a focused HeNe laser beam at different power levels. The time-varying reflected speckle pattern (which is recorded with a video camera and filed in a computer memory) rapidly changes in the early heating stage and then remains progressively at rest. The difference between pairs of time-consecutive images is measured by adding the squared differences of intensities at corresponding pixels. This allows one to define a speed of variation D(t) of the reflected image. It is shown that the time-law D(t) is similar to the function describing the derivative of sample temperature with respect to heating time (t). This supports the hypothesis that the observed effect is due to thermal dilatation of biological material forming the clot.

Citation Download Citation

German Da Costa "Time-resolved analysis of laser-induced photothermal stress in blood clots", Proc. SPIE 2137, Time-Resolved Laser Spectroscopy in Biochemistry IV, (17 August 1994); https://doi.org/10.1117/12.182731

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