Extent of left ventricular systolic dysfunction during acute coronary occlusion is load dependent

Robert M. Weiss M.D.

doi:10.1117/12.174391

1 May 1994 Extent of left ventricular systolic dysfunction during acute coronary occlusion is load dependent

Robert M. Weiss M.D.

Proceedings Volume 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images; (1994) https://doi.org/10.1117/12.174391
Event: Medical Imaging 1994, 1994, Newport Beach, CA, United States

Abstract

When analysis of global and regional left ventricular function is utilized to assess ischemic zone size, it is assumed: (1) a predictable relationship exists between the two; and (2) this relationship is not significantly affected by changes in loading conditions. This study examined the relationship between ischemic zone size and ventricular performance in 11 anesthetized paced dogs subjected to acute coronary occlusion. Cardiac cine-computed tomography was used to quantify regional and global left ventricular function. Ischemic zone size was quantified autoradiographically following left atrial microsphere injection. Both global and regional left ventricular function were strongly influenced by changes in ventricular loading. We conclude: (1) both global and regional left ischemic dysfunction are only modestly correlated with ischemic zone size during acute coronary occlusion; and (2) estimates of ischemic zone size using measurements of ventricular function are highly load-sensitive.

Citation Download Citation

Robert M. Weiss M.D. "Extent of left ventricular systolic dysfunction during acute coronary occlusion is load dependent", Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); https://doi.org/10.1117/12.174391

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