Intracellular uptake kinetics of hypocrellin photosensitizers for photodynamic therapy

Gerald G. Miller; Kevin Brown; Ronald B. Moore; Zhenjun Diwu; Jixiang Liu; Liren Huang; J. William Lown; David A. Begg; Vera Chlumecky; John Tulip; Malcolm S. McPhee

doi:10.1117/12.203432

1 March 1995 Intracellular uptake kinetics of hypocrellin photosensitizers for photodynamic therapy

Gerald G. Miller, Kevin Brown, Ronald B. Moore, Zhenjun Diwu, Jixiang Liu, Liren Huang, J. William Lown, David A. Begg, Vera Chlumecky, John Tulip, Malcolm S. McPhee

Author Affiliations +

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203432
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Hypocrellins are naturally occurring compounds with photosensitizing properties in biological systems. We have prepared synthetic derivatives of hypocrellin B, which have promise as photosensitizers in the clinical application of photodynamic therapy. The inherent fluorescence of four selected compounds has provided a means of determining their uptake and distribution in monolayer cultures of EMT6/Ed murine tumor cells, via fluorescence confocal microscopy.

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Gerald G. Miller, Kevin Brown, Ronald B. Moore, Zhenjun Diwu, Jixiang Liu, Liren Huang, J. William Lown, David A. Begg, Vera Chlumecky, John Tulip, and Malcolm S. McPhee "Intracellular uptake kinetics of hypocrellin photosensitizers for photodynamic therapy", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203432

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