Mechanism of photodynamic therapy (PDT): investigation of sensitizer dose and light dose-rate effects

Takeshi Takemura; Shiro Umeuchi; Susumu Nakajima; Isao Sakata

doi:10.1117/12.203374

1 March 1995 Mechanism of photodynamic therapy (PDT): investigation of sensitizer dose and light dose-rate effects

Takeshi Takemura, Shiro Umeuchi, Susumu Nakajima, Isao Sakata

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203374
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

The thresholds in sensitizer concentration and in light dose rate for PDT effects have been examined on the basis of a chemical reaction. The examination revealed that there exists basically no thresholds of drug and light dose-rate effects in PDT, but apparently there does. Also it was suggested that PDT effects depend largely on peak power of laser and not so largely on the total joule. And for PDT the use of pulse laser with relatively high peak power is better than the use of the lower one, especially cw laser.

Citation Download Citation

Takeshi Takemura, Shiro Umeuchi, Susumu Nakajima, and Isao Sakata "Mechanism of photodynamic therapy (PDT): investigation of sensitizer dose and light dose-rate effects", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203374

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available