Tumor-associated macrophages (not tumor cells) are the determinants of photosensitizer tumor localization

Mladen Korbelik; Gorazd Krosl

doi:10.1117/12.203372

1 March 1995 Tumor-associated macrophages (not tumor cells) are the determinants of photosensitizer tumor localization

Mladen Korbelik, Gorazd Krosl

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203372
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

The distribution of Photofrin and several other photosensitizers among major cellular populations contained in solid mouse tumors was examined using flow cytometry. Seven tumor models were included in the analysis: sarcomas EMT6, KHT, RIF, FsaR and FsaN, Lewis lung carcinoma and squamous cell carcinoma SCCVII. In all these tumors, the highest photosensitizer levels were found in a subpopulation of tumor associated macrophages consisting of activated cells (as suggested by their increased size, granularity, and the number of interleukin 2 receptors). There was no evidence of selective photosensitizer accumulation in malignant tumor cells. Results consistent with these observations were also obtained with the carcinogen induced squamous cell carcinoma growing in hamster cheek pouch.

Citation Download Citation

Mladen Korbelik and Gorazd Krosl "Tumor-associated macrophages (not tumor cells) are the determinants of photosensitizer tumor localization", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203372

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