Preventing restenosis in atherosclerotic miniswine with photodynamic therapy

York N. Hsiang M.D.; M. Teresa Crespo; Eleanor C. To; Mohammed S. Sobeh; Stephen E. Greenwald; Robert D. Bower

doi:10.1117/12.209124

12 May 1995 Preventing restenosis in atherosclerotic miniswine with photodynamic therapy

York N. Hsiang M.D., M. Teresa Crespo, Eleanor C. To, Mohammed S. Sobeh, Stephen E. Greenwald, Robert D. Bower

Proceedings Volume 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V; (1995) https://doi.org/10.1117/12.209124
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

The purpose of this study was to determine whether the addition of Photodynamic Therapy (PDT) using the photosensitizer Photofrin^* (P^*) following balloon angioplasty (BA) could prevent restenosis in an atherosclerotic animal model. Bilateral iliac atherosclerosis was created in 21 Yucatan miniswine. Six weeks later, P^* 2.5 mg/kg was given IV 24 hours prior to BA (4 mm X 20 mm, 1 inflation). Following BA, swine were randomly allocated to receive PDT via a fiberoptic probe with laser energy or the same probe without laser energy. The fiberoptic probe had a 1 cm cylindrical diffusing tip and was passed co-axially through a custom catheter to ensure central location of the probe. A continuous wave argon ion-pumped dye laser tuned to 630 nm was used to provide a fluence of 100 J/cm². Four weeks later, swine were sacrificed and vessels perfusion-fixed in-situ with glutaraldehyde and analyzed by ocular micrometry. Five occlusions occurred, all in the PDT + BA group. Percentage intimal thickness (mean +/- SD) was 51.0 +/- 29.5 in the BA group and 71.2 +/- 35.2 in the BA + PDT group (p equals 0.21). These results suggest that the addition of PDT following BA does not prevent restenosis.

Citation Download Citation

York N. Hsiang M.D., M. Teresa Crespo, Eleanor C. To, Mohammed S. Sobeh, Stephen E. Greenwald, and Robert D. Bower "Preventing restenosis in atherosclerotic miniswine with photodynamic therapy", Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); https://doi.org/10.1117/12.209124

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