Spectral diagnosis of human coronary artery: a clinical system for real-time analysis

John R. Kramer Jr.; James F. Brennan III; Tjeerd J. Roemer; Yang Wang; Ramachandra R. Dasari; Michael S. Feld

doi:10.1117/12.209123

12 May 1995 Spectral diagnosis of human coronary artery: a clinical system for real-time analysis

John R. Kramer Jr., James F. Brennan III, Tjeerd J. Roemer, Yang Wang, Ramachandra R. Dasari, Michael S. Feld

Proceedings Volume 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V; (1995) https://doi.org/10.1117/12.209123
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

In vitro studies have shown that normal and abnormal human coronary artery segments can be differentiated on the basis of their Raman spectra. A compact near infrared Raman spectroscopy system has been constructed for in vivo measurement of the biochemical composition of human coronary artery. A 500 mW air-cooled diode laser generates 830 nm excitation light which is delivered via a fiber optic probe to the arterial wall. Scattered light is collected by the same optical probe and delivered to a f/1.8 imaging spectrograph, which disperses the light onto a liquid-nitrogen-cooled deep-depletion CCD detector. A spectral model has been developed to quantify the protein, lipid and calcium mineral content in coronary artery wall. Raman spectra with sufficiently high S/N for extracting biochemical information can be collected in less than one second. In vivo studies during open heart surgery are currently being conducted which will establish near infrared Raman techniques as a real- time diagnostic tool.

Citation Download Citation

John R. Kramer Jr., James F. Brennan III, Tjeerd J. Roemer, Yang Wang, Ramachandra R. Dasari, and Michael S. Feld "Spectral diagnosis of human coronary artery: a clinical system for real-time analysis", Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); https://doi.org/10.1117/12.209123

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