Peripheral substitution of pheophorbides and bacteriopheophorbides to promote inclusion into inert carrier systems for PDT

Susanne Roehrs; Anja Ruebner-Heuermann; G. Hartwich; H. Scheer; Joerg G. Moser

doi:10.1117/12.230958

31 January 1996 Peripheral substitution of pheophorbides and bacteriopheophorbides to promote inclusion into inert carrier systems for PDT

Susanne Roehrs, Anja Ruebner-Heuermann, G. Hartwich, H. Scheer, Joerg G. Moser

Author Affiliations +

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230958
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Pheophorbide a ethyl ester, pyropheophorbide a ethyl ester, and bacteriopheophorbide ethyl ester were substituted in 3¹-position with tert.butyl phenoxy or tert.butyl benzoic acid ester groups resp. in order to enhance affinity to (beta) -cyclodextrin dimers which form inclusion complexes with these photosensitizing drugs. This is a first step to construct inert transport complexes in order to photosensitize specifically cancer cells.

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Susanne Roehrs, Anja Ruebner-Heuermann, G. Hartwich, H. Scheer, and Joerg G. Moser "Peripheral substitution of pheophorbides and bacteriopheophorbides to promote inclusion into inert carrier systems for PDT", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230958

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