Photodynamic therapy (PDT) in advanced inoperable bronchial carcinoma

Keyvan Moghissi; Kate Dixon; Mark R. Stringer; Stanley B. Brown

doi:10.1117/12.260700

3 December 1996 Photodynamic therapy (PDT) in advanced inoperable bronchial carcinoma

Keyvan Moghissi, Kate Dixon, Mark R. Stringer, Stanley B. Brown

Proceedings Volume 2922, Laser Applications in Medicine and Dentistry; (1996) https://doi.org/10.1117/12.260700
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

Objective: To assess the efficacy of PDT to: Palliate symptoms, control disease and extend survival in patients with advanced inoperable cancer. Subject and Method: 55 Males and 23 females aged between 45-81 years (mean 66 years) with inoperable and advanced lung cancer with > 5O. obstructive lesions of the main, lobar or segmental bronchi. Patients had pre-treatment routine clinical radiological, functional and endoscopic assessment with proven histological diagnosis. Protocol of PDT was; Intravenous injection of 2 mg/Kg bodyweight Polyhaematoporphyrin (equivalent to Photofrin) or Photofrin followed 24-72 hours later by illumination of tumour using 630 nm light (Oxford Laser) delivered via an optical fibre with end diffuser. Treatments were carried out under general anaesthesia as a day case procedure. Patients were rebronchoscoped for debridement/retreatment 4-7 days later. Results: There was no treatment related mortality. Two patients developed mild photosensitivity reaction. All patients showed symptomatic improvement with good initial functional and radiological amelioration. Every patient responded to treatment. Seven patients had complete response and negative histology for 3-12 months. After the first treatment average Forced Vital Capacity (FVC) and Forced Expiratory Volume in one second (FEV1) improvement was 0.5 litres and 0.4 litres respectively. Twenty five percent of patients (nr 19) survived more than 2 years, 10'. (nr=8) between 1-2 years and the remaining 51 patients less than a year. Conclusion: PDT should be considered as a therapeutic modality for all stages of lung cancer and is an excellent treatment modality for palliation in advanced bronchial malignancies.

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Keyvan Moghissi, Kate Dixon, Mark R. Stringer, and Stanley B. Brown "Photodynamic therapy (PDT) in advanced inoperable bronchial carcinoma", Proc. SPIE 2922, Laser Applications in Medicine and Dentistry, (3 December 1996); https://doi.org/10.1117/12.260700

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KEYWORDS

Photodynamic therapy

Lung cancer

Cancer

Endoscopy

Diffusers

YAG lasers

Biopsy

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