Laser fluorescence investigation of chlorin e6 pharmacokinetics

Vladimir A. Hovanessian; Asatour Lalaian; Grigor Gyulkhandanyan

doi:10.1117/12.260784

4 December 1996 Laser fluorescence investigation of chlorin e₆ pharmacokinetics

Vladimir A. Hovanessian, Asatour Lalaian, Grigor Gyulkhandanyan

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260784
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

The pharmacokinetic behavior of chlorin e₆ in different organs and tumor tissues of rats infected with Sarcoma-45 has been investigated with help of the fiber-optic spectrofluorometer at excitation by harmonics of YAG:Nd laser ((lambda) equals 355, 532 and 660 nm). The most intensive chlorine e₆ fluorescence in tumor tissue was observed in 18 hours after pigment injection. The optimal time of fluorescence diagnosis has been determined (in 27 hours after pigment injection). The maximum of the tumor-to- normal tissue ratio of fluorescence was equal 10 at 666 nm. The rates of the accumulation and elimination of chlorin e₆ in the skin, hypodermic tissues and tumors of rats were determined in vivo.

Citation Download Citation

Vladimir A. Hovanessian, Asatour Lalaian, and Grigor Gyulkhandanyan "Laser fluorescence investigation of chlorin e₆ pharmacokinetics", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260784

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available