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Although NAD/NADH and their spectroscopical characteristics have been well known for a relatively long time, the use of NADH-fluorescence measurements for clinical diagnostics is rather rare up to now Probing the application of a multifiber-NADH-fluorescence-measuring-apparatus in different fields of clinical research and clinical practice, the wide span of applicability is demonstrated. The main purpose of NADH-fluorescence diagnosis is to monitor the well-functioning of the respiratory chain, i.e. the energy metabolic situation of the tissue area probed. As a typical example, the observation of the metabolic state of tissue in transplantation surgery is considered on the one hand and the usefulness of the topological recognition of tumor areas on the other hand.
Werner Schramm,Wolfgang Hoehne,Herbert G. Stepp, andAndreas Leunig
"Noninvasive NADH measurements for clinical applications", Proc. SPIE 2927, Optical and Imaging Techniques for Biomonitoring II, (11 December 1996); https://doi.org/10.1117/12.260634
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Werner Schramm, Wolfgang Hoehne, Herbert G. Stepp, Andreas Leunig, "Noninvasive NADH measurements for clinical applications," Proc. SPIE 2927, Optical and Imaging Techniques for Biomonitoring II, (11 December 1996); https://doi.org/10.1117/12.260634