First experience of application of photodynamic therapy in keratoplasty

Svyatoslav N. Fyodorov; V. G. Kopayeva; Yu. V. Andreev; Eugeny Ph. Stranadko; G. V. Ponomariov

doi:10.1117/12.260884

5 December 1996 First experience of application of photodynamic therapy in keratoplasty

Svyatoslav N. Fyodorov, V. G. Kopayeva, Yu. V. Andreev, Eugeny Ph. Stranadko, G. V. Ponomariov

Proceedings Volume 2930, Lasers in Ophthalmology IV; (1996) https://doi.org/10.1117/12.260884
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

Vascular effect of photodynamic therapy has been studied in patients with corneal neovascularized transplant in 10 cases. THe injection of photoheme intravenously were made with subsequent irradiation by light of argon-pumped dye laser with light density of 150-300 mW/cm² for 10-15 minutes. Energy density consisted 150-300 J/cm². In all the cases at the time of irradiation the aggregated blood flow was appeared followed by blood flow stasis. In post- operative period the vessels disintegrated into separate fragments which disappeared completely after 10-15 days. Taking into account the data of light microscope, the disappearance of the vessels took place as a result of the vascular endothelium lysis along the vascular walls. The vessel alteration study presented in this paper, may also serve to specify the mechanism of photodynamic destruction of neovascularized stroma of tumor.

Citation Download Citation

Svyatoslav N. Fyodorov, V. G. Kopayeva, Yu. V. Andreev, Eugeny Ph. Stranadko, and G. V. Ponomariov "First experience of application of photodynamic therapy in keratoplasty", Proc. SPIE 2930, Lasers in Ophthalmology IV, (5 December 1996); https://doi.org/10.1117/12.260884

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