Systemic estimation of the effect of photodynamic therapy of cancer

Eugenia A. Kogan; Gennadii A. Meerovich; Nadezgda L. Torshina; Victor B. Loschenov; Anna I. Volkova; Anna M. Posypanova

doi:10.1117/12.297803

29 December 1997 Systemic estimation of the effect of photodynamic therapy of cancer

Eugenia A. Kogan, Gennadii A. Meerovich, Nadezgda L. Torshina, Victor B. Loschenov, Anna I. Volkova, Anna M. Posypanova

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297803
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The effects of photodynamic therapy (PDT) of cancer needs objective estimation and its unification in experimental as well as in clinical studies. They must include not only macroscopical changes but also the complex of following morphological criteria: (1) the level of direct tumor damage (direct necrosis and apoptosis); (2) the level of indirect tumor damage (ischemic necrosis); (3) the signs of vascular alterations; (4) the local and systemic antiblastome resistance; (5) the proliferative activity and malignant potential of survival tumor tissue. We have performed different regimes PDT using phthalocyanine derivatives. The complex of morphological methods (Ki-67, p53, c-myc, bcl-2) was used. Obtained results showed the connection of the tilted morphological criteria with tumor regression.

Citation Download Citation

Eugenia A. Kogan, Gennadii A. Meerovich, Nadezgda L. Torshina, Victor B. Loschenov, Anna I. Volkova, and Anna M. Posypanova "Systemic estimation of the effect of photodynamic therapy of cancer", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297803

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available